Injuries are always a huge factor when setting your weekly fantasy lineup, but this week's schedule puts owners in an even bigger lurch than usual. Week 10 presents us with the usual dose of game-time decisions, but the fact that several of them fall in the Sunday and Monday night prime-time affairs puts owners in a terrible situation. Specifically, if Marvin Harrison, Dallas Clark and Deion Branch are ruled out, chances are most of your bench options will have already played. Thus, you have to ask yourself: can you really afford to wait to see if they are active? Well, let's look at them on a case-by-case basis.

1. Colts WR Marvin Harrison: Marv has missed the last two games, and the better part of four overall, with his knee injury, so it's clearly not a minor injury. You could wait and see if Marv is listed as active and starting on Sunday night, especially if you're desperate at wideout, but you cannot afford to not have a backup ready to go in the event he's not dressing. Your options are fairly limited since the only teams still playing will be Indy, San Diego, Seattle and San Fran. If you have Chris Chambers, Bobby Engram, or D.J. Hackett, you're in fine shape. Other than that, your options are pretty lackluster, including Nate Burleson, Vincent Jackson, Arnaz Battle and Darrell Jackson. If those are your only free-agent options -- and don't forget you may have to add them to your roster before the early kickoffs -- I'd probably lean toward blowing Marv off and using your best early-game reserve. After all, let's not forget that Marv is no lock to play every snap and produce even if he is active.

2. Colts TE Dallas Clark: Clark missed Wednesday and Thursday workouts with a concussion but did participate in limited fashion on Friday. If this weren't a late game, it would be far less problematic. But if Clark is ruled out, you're left with options such as Colts backup TE Ben Utecht and Seahawks TE Will Heller. Seeing that, if you carry two TEs and have a nice play ready to go like Heath Miller or Greg Olsen, I would recommend that. If you're looking at a Utecht-level play either way, I'd roll the dice on Clark and resort to Utecht if necessary. 

3. Seahawks WR Deion Branch: With a Monday nighter on tap, the Seahawks get a chance to work Branch out on Saturday, and he did participate in limited fashion on Friday for the first time since sustaining his foot injury. He's likely to be a game-time decision, but two workouts would indicate to me that he'll be ready. If your lineup has produced without Branch the last month, I wouldn't mess with waiting on Branch. But if you're desperate, I don't mind the gamble, especially if you can add a Burleson, Jackson or Battle and have them waiting in the wings just in case.